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Farmakologik guruh

: Antiaritmik IB

Class IB:

Lidocaine, phenytoin, mexiletine.
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Mechanism:

Weak Na+ channel blockade. ⬇️ AP duration. Preferentially affect ischemic or depolarized Purkinye anda ventricular tissue.

Clinical use:

Acute ventricular arrtytmias (especial post MI), digitalis- induced arrtytmias. IB is Best post - MI.

Adverse effekts:

CNS stimulation/depression, cardivascular depression.